کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3399397 | 1222518 | 2010 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Anaplasma phagocytophilum and Ehrlichia chaffeensis type IV secretion and Ank proteins Anaplasma phagocytophilum and Ehrlichia chaffeensis type IV secretion and Ank proteins](/preview/png/3399397.png)
The obligatory intracellular bacterial pathogens Anaplasma and Ehrlichia infect leukocytes by hijacking host-cell components and processes. The type IV secretion system is up-regulated during infection. Among type IV secretion candidate substrates, an ankyrin repeat protein of Anaplasma phagocytophilum, AnkA, is delivered into the host cytoplasm via a complex that includes VirD4. AnkA is highly tyrosine phosphorylated and binds to the Abl interactor 1, SHP-1, and nuclear DNA fragments. Ehrlichia chaffeensis AnkA was recently reported to be translocated into host-cell nucleus. The recent discovery of several ankyrin repeat proteins secreted via the type IV secretion system of different intracellular bacteria suggests that a common strategy evolved to subvert host-cell functions.
Journal: Current Opinion in Microbiology - Volume 13, Issue 1, February 2010, Pages 59–66