کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3404585 | 1593255 | 2009 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Combination Antimicrobial Treatment Versus Monotherapy: The Contribution of Meta-analyses
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماری های عفونی
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چکیده انگلیسی
Interactions between antibiotic combinations predicted by in vitro studies are not consistently reflected in clinical trials. Beta-lactam–aminoglycoside combinations, synergistic in vitro, do not confer improved survival or cure and do not prevent breakthrough infections. These conclusions are derived from recent systematic reviews and meta-analyses of randomized, controlled trials. Often, pertinent clinical outcomes could not be assessed meaningfully in individual randomized trials, but their compilation leads to strong conclusions relating to outcomes that affect the individual patient. Systematic reviews have made possible the evidence-based use of antibiotic combinations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Infectious Disease Clinics of North America - Volume 23, Issue 2, June 2009, Pages 277–293
Journal: Infectious Disease Clinics of North America - Volume 23, Issue 2, June 2009, Pages 277–293
نویسندگان
Mical Paul, Leonard Leibovici,