کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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340839 | 548368 | 2007 | 6 صفحه PDF | دانلود رایگان |
SummaryPurposeIn infants with frequent therapy resistant seizures (TRS-infants), clinical detection of pyridoxine-dependency (PD) or -responsiveness (PR) occurs by empirical intravenous (IV) pyridoxine administration during recording of the EEG. However, in undiagnosed TRS-infants it is still unclear to what extent EEG alterations by pyridoxine-IV are attributable to PD/PR or to non-specific responses. Before EEG alterations by pyridoxine-IV can be ascribed to PD/PR, these non-specific responses should be excluded first.MethodsIn 10 TRS-infants under 1 year of age, we determined the EEG effect by pyridoxine-IV on the EEG-recording.ResultsAfter pyridoxine-IV administration, our data indicate declined (10–15%; p < 0.05) EEG-amplitudes and total power (magnitude/frequency-band) at frontal, central and centro-temporal electrodes.ConclusionIn TRS-infants, pyridoxine-IV affects EEG-amplitude and -total power in a non-specific way, which does not identify PD/PR.
Journal: Seizure - Volume 16, Issue 5, July 2007, Pages 459–464