کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
340876 548376 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Correlation of MRI and histopathology in epileptogenic parietal and occipital lobe lesions
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Correlation of MRI and histopathology in epileptogenic parietal and occipital lobe lesions
چکیده انگلیسی

SummaryIntroductionTo analyze the diagnostic accuracy of MRI in patients undergoing parietal and occipital lobe epilepsy surgery.MethodsIn a retrospective study, we analyzed MRI scans and neuropathology reports of 42 patients who had undergone resective epilepsy surgery in the parietal and occipital lobe between 1998 and 2003. We evaluated, whether lesions were precisely characterized by MRI and whether lesion characterization allowed to estimate postsurgical seizure outcome.ResultsWithin the categories epilepsy associated tumors, focal cortical dysplasias, vascular malformations, scarring, and others, MRI was concordant with histopathology in 36 of 42 (86%) lesions. Among the discordant lesions, one lesion was re-classified following MRI–histopathology synopsis, another two lesions represented new tumor entities (angiocentric neuroepithelial tumor, isomorphic astrocytoma) which have been described recently. Seizure freedom (Engel class I) one year following surgery was achieved in 25 patients (60%). Seizure outcome was different for lesion categories (Engel class I: epilepsy associated tumors, 62%; focal cortical dysplasias, 71%; vascular malformations, 75%; scarring, 40%), and was unchanged if no lesion was found on preoperative MRI.ConclusionIf MRI and histopathology are discordant, not only the MRI findings may be debatable. MRI lesion detection is important, since chance of seizure freedom is low if no lesion is detected.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seizure - Volume 16, Issue 7, October 2007, Pages 608–614
نویسندگان
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