کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3416307 1593696 2016 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
CagA-mediated pathogenesis of Helicobacter pylori
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروب شناسی
پیش نمایش صفحه اول مقاله
CagA-mediated pathogenesis of Helicobacter pylori
چکیده انگلیسی


• Helicobacter pylori is a pathogen of human, causing various infection-related morbidities i.e, gastritis and adenocarcinoma.
• Majority of the pathophysiologic effects of H. pylori infection are linked to its CagA as the first bacterial oncoprotein.
• A 40-kb DNA region, called cag pathogenicity island (cagPAI), encodes CagA and subunits of H. pylori Type 4 secretion system.
• Interactions between CagA and host proteins trigger the development of inflammatory responses and multi-step gastric cancer.
• Structure-function analysis of CagA helps to elucidate the infection mechanism by H. pylori and develop therapeutic options.

Helicobacter pylori has been described as the main etiologic agent of gastric cancer, causing a considerable rate of mortality and morbidity in human population across the world. Although the infection mainly begins asymptomatically, but simply develops to peptic ulcer, chronic gastritis, lymphoma of the gastric mucosa and eventually adenocarcinoma. The major pathological feature of H. pylori infection is due to the activity of the cytotoxin-associated gene A (CagA), a 125–140 kDa protein encoded by the cag pathogenicity island (cagPAI). CagA is also known as the first bacterial onco-protein, ranking the H. pylori-mediated adenocarcinoma as the second most deadly cancer type worldwide. Upon cytoplasmic translocation CagA undergoes interacting with numerous proteins in phosphorylation dependant and independent manners within the gastric epithelial cells. The profound effect of CagA on multiple intracellular pathways causes major consequences such as perturbation of intracellular actin trafficking, stimulation of inflammatory responses and disruption of cellular tight junctions. Such activities of CagA further participate in development of the hummingbird phenotype and gastric cancer. This review is sought to provide a structural and functional analysis of the CagA protein with focus on demonstrating the molecular basis of the mechanism of CagA intracellular translocation and its interaction with intracellular targets.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbial Pathogenesis - Volume 93, April 2016, Pages 44–55
نویسندگان
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