Biocompatibility and antibacterial activity of the Adathoda vasica Linn extract mediated silver nanoparticles

• Silver nanoparticles preparation using Adathoda vasica.
• Synthesized nanoparticles acted as effective bactericidal agent.
• Vibrio parheamolyticus and silver nanoparticles inter action study in CLSM.
• An excellent Artemia naupilli biocompatibility was attained in vivo analysis.

The aim of this study is to investigate the biocompatibility and anti-Vibrio efficacy of green synthesized silver nanoparticles (AgNPs) using an aqueous leaf extract of Adathoda vasica (A. vasica). The green synthesized silver nanoparticles were characterized by UV–vis, Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM) and energy dispersive X-ray analysis (EDX). A. vasica AgNPs showed significant antibacterial activity against Vibrio parahaemolyticus in agar bioassay and well diffusion method. Further, nanoparticles interactions with bacteria and its antibacterial activity were confirmed by CLSM analysis. In vivo evaluation results confirmed that synthesized A. vasica AgNPs had good antibacterial efficacy and also nontoxic to the Artemia nauplii.

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