کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3416455 1593700 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An investigation and evaluation on species and characteristics of pathogenic microorganisms in Chinese local hospital settings
ترجمه فارسی عنوان
بررسی و ارزیابی گونه ها و ویژگی های میکروارگانیسم های بیماریزا در محیط های محلی بیمارستان های چینی
کلمات کلیدی
مقاومت ضد میکروبی، تنظیمات بیمارستان، میکروارگانیسم ها، سمی بودن
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروب شناسی
چکیده انگلیسی


• We isolated 26 distinct bacterial strains from a Chinese hospital.
• There genera were determined, and a MIC evaluation was performed.
• Eight strains were resistant to a chlorine-containing disinfectant.
• Twelve strains were resistant to Povidone–iodine.
• Strain 14 killed all silkworms within 12 h with an LD50 of 4 × 104 CFU/larva.

There are currently great concerns about the level of bacterial contamination in hospitals, as well as resistance to antimicrobial agents. The species and characteristics of microbes in Chinese hospitals are closely related to healthcare safety and the prevention and control of infections. However, data on the exposure of patients to microbes in Chinese hospitals are limited. The present study investigated the genera of microorganisms in Chinese hospitals. We evaluated their characteristics, such as antibiotic susceptibility, tolerance to disinfectants, and toxicity, using silkworms (Bombyx mori) as an animal model. Twenty-six distinct bacterial strains were isolated, and their genera were determined by sequencing their 16S rDNA regions. Twenty-five strains were resistant to one or more antibiotics, and six strains were resistant to multiple antibiotics. The results of minimal inhibitory concentration testing showed that eight strains were resistant to a chlorine-containing disinfectant, and 12 strains were resistant to Povidone–iodine. Following the injection of bacterial cultures into the silkworm hemolymph, 15 strains killed all of the silkworms within 5 d. Additionally, bacterial strain 14 killed all of silkworms within 12 h with a median lethal dose of 4 × 104 colony-forming units/larva. This study provides useful information for healthcare safety in Chinese hospitals.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbial Pathogenesis - Volume 89, December 2015, Pages 154–160
نویسندگان
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