کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3417080 1225177 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Superantigens SPEA and SMEZ do not affect secretome expression in Streptococcus pyogenes
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروب شناسی
پیش نمایش صفحه اول مقاله
Superantigens SPEA and SMEZ do not affect secretome expression in Streptococcus pyogenes
چکیده انگلیسی

The superantigens, toxic shock syndrome toxin-1 (TSST-1) and staphylococcal enterotoxin B (SEB), were recently reported to repress global exoprotein synthesis in Staphylococcus aureus. To investigate if this phenomenon could be observed in a different Gram-positive pathogen, the effects of two major Streptococcus pyogenes superantigens on streptococcal secretome expression were examined. Using mutagenesis and genetic complementation, we demonstrated that neither streptococcal pyrogenic exotoxin A (SPEA) nor streptococcal mitogenic exotoxin Z (SMEZ) had any consistent effect on global protein expression or on transcription of genes encoding the secreted exoproteins, DNase B, SPEB and SPEG. In S. pyogenes, superantigen production does not appear to have a major regulatory role.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbial Pathogenesis - Volume 44, Issue 6, June 2008, Pages 537–543
نویسندگان
, ,