کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3417217 1225190 2008 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Aeromonas hydrophila AH-3 AexT is an ADP-ribosylating toxin secreted through the type III secretion system
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروب شناسی
پیش نمایش صفحه اول مقاله
Aeromonas hydrophila AH-3 AexT is an ADP-ribosylating toxin secreted through the type III secretion system
چکیده انگلیسی

We cloned and sequenced an ADP-ribosylating toxin (AexT) from a mesophilic Aeromonas hydrophila strain AH-3 with a type III secretion system (T3SS). This toxin only showed homology, in genes and proteins, with the first half of A. salmonicida AexT. The A. hydrophila AexT showed ADP-ribosyltransferase activity, translocation through the T3SS system, and this A. hydrophila T3SS system is inducible under calcium-depleted conditions. The A. hydrophila aexT mutant showed a slight reduction in their virulence assayed by several methods when compared to the wild-type strain, while an A. hydrophila T3SS mutant is highly reduced in virulence on the same assays. The A. hydrophila AexT is the first described and the smallest T3SS effector toxin found in mesophilic Aeromonas with a functional T3SS.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbial Pathogenesis - Volume 44, Issue 1, January 2008, Pages 1–12
نویسندگان
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