کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3417261 | 1593738 | 2007 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Zinc-dependent cytoadherence of Legionella pneumophila to human alveolar epithelial cells in vitro Zinc-dependent cytoadherence of Legionella pneumophila to human alveolar epithelial cells in vitro](/preview/png/3417261.png)
Microbial adherence to host cells is an early key step in the establishment of infection. During the course of Legionnaire's disease, Legionella interactions with host cells are best documented for resident macrophages. However, L. pneumophila can also replicate within type I and type II pneumocytes, which cover almost the entire alveolar surface. In the presence of zinc, we observed a significant and concentration-dependent increase in L. pneumophila adherence to and invasion of type II pneumocytes. The zinc-dependent adherence mechanism seemed to be host-cell-independent, as a similar increase in cytoadherence was observed with macrophages. We also found that zinc-dependent adherence of L. pneumophila appears to involve recognition of zinc-binding pneumocyte receptors by a bacterial adhesin, and heparan-sulfated host cell receptors, but not type IV pili.
Journal: Microbial Pathogenesis - Volume 43, Issues 5–6, November–December 2007, Pages 234–242