کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3417278 | 1225196 | 2008 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: SPG/IND-induced septic shock in a LPS-low responder strain, C3H/HeJ mice SPG/IND-induced septic shock in a LPS-low responder strain, C3H/HeJ mice](/preview/png/3417278.png)
The administration of β-glucan (sonifilan; SPG) in combination with a non-steroidal anti-inflammatory drug, indomethacin (IND), induced lethal septic shock in mice. To demonstrate the influence of bacterial lipopolysaccharide (LPS) in this lethal toxicity, LPS non-responder C3H/HeJ mice were used to compare features of sepsis and physicochemical parameters in the present study. The administration of SPG and IND induced the death of C3H/HeJ mice, lowering rectal temperature, reducing body weight, increasing serum tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels, shortening the gastrointestinal tract, and increasing the GOT/GPT level. Microbial translocation to various organs was also significantly increased. These results strongly suggested that LPS-non-responding strain also induced septic shock in this experimental model, and other pathogen-associated molecular patterns (PAMPs) may significantly contribute to the septic shock.
Journal: Microbial Pathogenesis - Volume 44, Issue 5, May 2008, Pages 402–409