کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3417726 1225463 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Quantitative assessment of the effects of sulfamethoxazole on Toxoplasma gondii loads in susceptible WT C57BL/6 mice as an immunocompetent host model
ترجمه فارسی عنوان
ارزیابی کمی اثر سولفامتوکسازول بر بارهای توکسوپلاسما گوندی در موش های حساس WT C57BL / 6 به عنوان یک مدل میزبان سیستم ایمنی بدن
کلمات کلیدی
Toxoplasma gondii؛ میزبان سیستم ایمنی؛ سولفامتوکسازول؛ QC-PCR
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی انگل شناسی
چکیده انگلیسی


• We evaluated the effects of sulfamethoxazole (SMX) on T. gondii in C57BL/6 mice.
• SMX prolonged the survival time and decreased the parasite loads in the organs.
• SMX could not eradicate T. gondii from the brain, heart and lung.
• SMX concentration was higher in the infected mice than in the uninfected mice.

The abundance of Toxoplasma gondii with or without sulfamethoxazole (SMX) treatment was evaluated with quantitative competitive polymerase chain reaction in various organs of wild-type C57BL/6 mice, a susceptible immunocompetent host, after peroral infection with a cyst-forming Fukaya strain of T. gondii. SMX affected different organs in three ways: T. gondii was reduced independently of SMX (skin and kidney); T. gondii was not eradicated with continuous treatment (brain, heart, and lung); and T. gondii was eradicated with continuous treatment (tongue, skeletal muscle, and small intestine). The SMX concentrations in the brains, hearts, and lungs were higher in infected mice than in uninfected mice. These results indicate that even in an immunocompetent host, chemotherapy is necessary to reduce the parasite load and thus reduce the risk of recurrent disease.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Parasitology International - Volume 65, Issue 1, February 2016, Pages 1–4
نویسندگان
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