کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3417757 1225469 2014 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structural comparison of lipophosphoglycan from Leishmania turanica and L. major, two species transmitted by Phlebotomus papatasi
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی انگل شناسی
پیش نمایش صفحه اول مقاله
Structural comparison of lipophosphoglycan from Leishmania turanica and L. major, two species transmitted by Phlebotomus papatasi
چکیده انگلیسی


• LPG is a multivirulence factor in Leishmania.
• LPG is crucial for parasite attachment in the midgut of the sand fly vector.
• The LPG of L. turanica displays similarities to L. major's.
• L. turanica is able to sustain infection in Phlebotomus papatasi.

The lipophosphoglycan (LPG) of Leishmania major has a major role in the attachment to Phlebotomus papatasi midgut. Here, we investigated the comparative structural features of LPG of L. turanica, another species transmitted by P. papatasi. The mAb WIC 79.3, specific for terminal Gal(β1,3) side-chains, strongly reacted with L. turanica LPG. In contrast, L. turanica LPG was not recognized by arabinose-specific mAb 3F12. In conclusion, LPGs from L. major and L. turanica are similar, with the latter being less arabinosylated than L. major's. The high galactose content in L. turanica LPG is consistent with its predicted recognition by P. papatasi lectin PpGalec.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Parasitology International - Volume 63, Issue 5, October 2014, Pages 683–686
نویسندگان
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