کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3417780 1225471 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mannose-binding Lectin (MBL) as a susceptible host factor influencing Indian Visceral Leishmaniasis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی انگل شناسی
پیش نمایش صفحه اول مقاله
Mannose-binding Lectin (MBL) as a susceptible host factor influencing Indian Visceral Leishmaniasis
چکیده انگلیسی


• Visceral Leishmaniasis caused by L. donovani is endemic in the Indian sub-continent.
• The MBL2 variants were significantly associated with protection to VL.
• The MBL2*LYQA haplotype was also significantly associated with protection to VL.
• Increased MBL serum levels were observed in VL patients.
• MBL and their genetic variants play roles during VL caused by L. donovani.

Visceral Leishmaniasis (VL), caused by Leishmania donovani is endemic in the Indian sub-continent. Mannose-binding Lectin (MBL) is a complement lectin protein that binds to the surface of Leishmania promastigotes and results in activation of the complement lectin cascade. We utilized samples of 218 VL patients and 215 healthy controls from an Indian population. MBL2 functional variants were genotyped and the circulating MBL serum levels were measured. MBL serum levels were elevated in patients compared to the healthy controls (adjusted P = 0.007). The MBL2 promoter variants − 78C/T and + 4P/Q were significantly associated with relative protection to VL (− 78C/T, OR = 0.7, 95% CI = 0.5–0.96, adjusted P = 0.026 and + 4P/Q, OR = 0.66, 95% CI = 0.48–0.9, adjusted P = 0.012). MBL2*LYQA haplotypes occurred frequently among controls (OR = 0.69, 95% CI = 0.5–0.97, adjusted P = 0.034). MBL recognizes Leishmania and plays a relative role in establishing L. donovani infection and subsequent disease progression. In conclusion, MBL2 functional variants were associated with VL.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Parasitology International - Volume 64, Issue 6, December 2015, Pages 591–596
نویسندگان
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