کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3417794 1225472 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chemokines responses to Plasmodium falciparum malaria and co-infections among rural Cameroonians
ترجمه فارسی عنوان
واکسن هوموکین ها به مالاریا فالسیپاروم پلاسمودیوم و عفونت های مشترک در روستاهای کامرون است
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی انگل شناسی
چکیده انگلیسی


• The mean concentration of CXCL11 was higher in symptomatic than asymptomatic group.
• Lower chemokine levels were associated with symptoms of uncomplicated malaria.
• CXCL11 was upregulated among fever-positive group.
• CXCL5 level was higher in malaria sole infection than co-infections with HIV and Loa loa.

Malaria remains the major cause of disease morbidity and mortality in sub-Saharan Africa with complex immune responses associated with disease outcomes. Symptoms associated with severe malaria have generally shown chemokine upregulation but little is known of responses to uncomplicated malaria. Eight villages in central Cameroon of 1045 volunteers were screened. Among these, malaria-positive individuals with some healthy controls were selected for chemokine analysis using Enzyme-Linked Immunosorbent Assay (ELISA) kits. Depressed serum levels of CXCL5 and raised CCL28 were observed in malarial positives when compared with healthy controls. The mean concentration of CXCL11 was higher in symptomatic than asymptomatic group, while CCL28 was lower in symptomatic individuals. Lower chemokine levels were associated with symptoms of uncomplicated malaria except for CXCL11 which was upregulated among fever-positive group. The mean CXCL5 level was higher in malaria sole infection than co-infections with HIV and Loa loa. Also, there was a raised mean level of malaria + HIV co-infection for CXCL9. This study hypothesises a situation where depressed chemokines in the face of clinical presentations could indicate an attempt by the immune system in preventing a progression process from uncomplicated to complicated outcomes with CXCL11 being identified as possible biomarker for malarial fever.

Relationship [correlation values (Y-axis)] between chemokines and malaria parasite load.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Parasitology International - Volume 64, Issue 2, April 2015, Pages 139–144
نویسندگان
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