کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
342073 548731 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The impact of the ketogenic diet on arterial morphology and endothelial function in children and young adults with epilepsy: A case–control study
ترجمه فارسی عنوان
تأثیر رژیم کتوژنیک بر مورفولوژی شریان و عملکرد اندوتلیال در کودکان و نوجوانان مبتلا به صرع: مطالعهی کنترل کایزا
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی

PurposeThe present study aimed to assess the impact of the ketogenic diet on arterial morphology and endothelial function of the big vessels of the neck and on cardiac diastolic function, in a cohort of epileptic children and young adults treated with the ketogenic diet.MethodsPatients were recruited based on the following inclusion criteria: (1) patients who were or had been on the ketogenic diet for a time period of at least six months. Each patient underwent measurement of carotid intima media thickness, carotid artery stiffness, echocardiography, and diastolic function assessment. Patients with drug resistant epilepsy, matched for number, age and sex and never treated with ketogenic diet, were recruited as controls.ResultsThe population study was composed by 43 epilepsy patients (23 males), aged between 19 months and 31 years (mean 11 years). Twenty-three patients were or had been treated with ketogenic diet, and 20 had never been on it (control group). Subjects treated with the ketogenic diet had higher arterial stiffness parameters, including AIx and β-index and higher serum levels of cholesterol or triglycerides compared to those who had never been on the diet (control group) (p < 0.001).ConclusionsArterial stiffness is increased in children and young adults treated with the ketogenic diet, before the increase of the intima media thickness. This supports that arterial stiffness is an early marker of vascular damage.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seizure - Volume 23, Issue 4, April 2014, Pages 260–265
نویسندگان
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