کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3421236 | 1594045 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evaluation of the Pastorex® meningitis kit for the rapid identification of Neisseria meningitidis serogroups A and W135
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Evaluation of the Pastorex® meningitis kit for the rapid identification of Neisseria meningitidis serogroups A and W135 Evaluation of the Pastorex® meningitis kit for the rapid identification of Neisseria meningitidis serogroups A and W135](/preview/png/3421236.png)
چکیده انگلیسی
The recent emergence of Neisseria meningitidis W135 as a cause of epidemic bacterial meningitis and the availability of a trivalent ACW135 vaccine have created a need for accurate and timely meningococcal serogroup determination for organization of epidemic vaccine response. The sensitivity and specificity of the Pastorex® meningitis kit (Bio-Rad) to identify serogroups A and W135 in the African meningitis belt was assessed using PCR testing as the gold standard. The sensitivity and specificity for serogroups A and W135 were 87 and 85%, respectively, while the specificities were 93 and 97%. The positive and negative likelihood ratios for A were 12 and 0.14 and for W135 were 33 and 0.16. The positive and negative predictive values, computed to simulate an epidemic of meningococcal meningitis with an estimated 70% prevalence of N. meningitidis among suspected cases, were 97% and 75% for A and 99% and 73% for W135. In remote locations of the African meningitis belt, latex agglutination is the only currently available test that can rapidly determine meningococcal serogroup. This study showed that latex agglutination performs well and could be used during the epidemic season to determine appropriate vaccine response.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene - Volume 100, Issue 6, June 2006, Pages 573-578
Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene - Volume 100, Issue 6, June 2006, Pages 573-578
نویسندگان
S. Djibo, B.-M. Njanpop Lafourcade, P. Boisier, A. Moussa, G. Kobo, F. Sidikou, A. Hien, G. Bieboure, J.-F. Aguilera, I. Parent du Chatelet, B.D. Gessner, S. Chanteau,