کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3421738 1226674 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The potential impact of coinfection on antimicrobial chemotherapy and drug resistance
ترجمه فارسی عنوان
اثر بالقوه سوء عفونت بر روی شیمی درمانی ضد میکروبی و مقاومت دارویی
کلمات کلیدی
مقاومت دارویی، عفونت مدولاسیون ایمنی، رقابت منابع تعاملات انگلی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروب شناسی
چکیده انگلیسی


• Resistance to antimicrobial chemotherapy is a growing global problem.
• Coinfection with multiple pathogens among humans and animals is very common.
• The role of coinfection in the dynamics of drug resistance is largely understudied.
• We review how coinfection can impact resistance, and we identify future research goals.

Across a range of pathogens, resistance to chemotherapy is a growing problem in both public health and animal health. Despite the ubiquity of coinfection, and its potential effects on within-host biology, the role played by coinfecting pathogens on the evolution of resistance and efficacy of antimicrobial chemotherapy is rarely considered. In this review, we provide an overview of the mechanisms of interaction of coinfecting pathogens, ranging from immune modulation and resource modulation, to drug interactions. We discuss their potential implications for the evolution of resistance, providing evidence in the rare cases where it is available. Overall, our review indicates that the impact of coinfection has the potential to be considerable, suggesting that this should be taken into account when designing antimicrobial drug treatments.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 23, Issue 9, September 2015, Pages 537–544
نویسندگان
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