| کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
|---|---|---|---|---|
| 3421913 | 1226696 | 2016 | 11 صفحه PDF | دانلود رایگان |
Human influenza viruses cause regular epidemics and occasional pandemics with a substantial public health burden. Household transmission studies have provided valuable information on the dynamics of influenza transmission. We reviewed published studies and found that once one household member is infected with influenza, the risk of infection in a household contact can be up to 38%, and the delay between onset in index and secondary cases is around 3 days. Younger age was associated with higher susceptibility. In the future, household transmission studies will provide information on transmission dynamics, including the correlation of virus shedding and symptoms with transmission, and the correlation of new measures of immunity with protection against infection.
TrendsHistorically, household cohort studies have provided valuable information on the incidence of respiratory infections and risk factors for infection. However, these studies require substantial resources and can provide limited information on transmission dynamics.Household transmission studies provide an efficient approach to describing the risk of influenza transmission and factors affecting transmission. In these studies, households with at least one member infected by influenza are eligible and are followed intensively for 1–2 weeks to observe secondary transmission within the household.Transmission studies also provide a model for evaluation of interventions in randomized controlled trials, and have been used to determine the efficacy of antiviral drugs for treatment and prophylaxis, and nonpharmaceutical interventions such as face masks and hand hygiene.
Journal: - Volume 24, Issue 2, February 2016, Pages 123–133