کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3421997 | 1226709 | 2013 | 7 صفحه PDF | دانلود رایگان |
Throughout the human lifetime, the intestinal microbiota performs vital functions, such as barrier function, metabolic reactions, trophic effects, and maturation of the host's innate and adaptive immune responses. Development of the intestinal microbiota in infants is characterized by rapid and large changes in microbial abundance, diversity, and composition. These changes are influenced by medical, cultural, and environmental factors such as mode of delivery, diet, familial environment, diseases, and therapies used. Thus, it is nearly impossible to define a universal standard for intestinal colonization and development of the intestinal microbiota. This review discusses recent data on the early colonization of the gut by microbial species, development of the intestinal microbiota, and its impact on health.
► A standard pattern for human intestinal microbiota colonization is unpredictable.
► Patients’ intestinal microbiota should be considered in designing personalized therapies.
► Microbiota colonization during the neonatal period is a key point for adult health.
► Limitation and rationalization of neonatal antibiotic treatments is urgently needed.
Journal: - Volume 21, Issue 4, April 2013, Pages 167–173