Streptococcus pneumoniae and reactive oxygen species: an unusual approach to living with radicals

Streptococcus pneumoniae, an aerotolerant anaerobe, is an important human pathogen that regularly encounters toxic oxygen radicals from the atmosphere and from the host metabolism and immune system. Additionally, S. pneumoniae produces large amounts of H2O2 as a byproduct of its metabolism, which contributes to its virulence but also has adverse effects on its biology. Understanding how S. pneumoniae defends against oxidative stress is far from complete, but it is apparent that it does not follow the current paradigm of having canonical enzymes to detoxify oxygen radicals or homologues of typical oxidative stress responsive global regulators. We will give an overview of how S. pneumoniae copes with oxygen radicals. Furthermore, we draw parallels with other pathogenic streptococcal species and provide future research perspectives.

► Repertoire of oxidative detoxification and repair mechanisms is unique for S. pneumoniae.
► Endogenous production of H2O2 shapes pneumococcal oxidative stress response.
► Regulation of oxidative stress resistance is largely unknown.
► Manganese and zinc are the main cations involved in oxidative stress.