کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3422091 1226719 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The role of toxin A and toxin B in the virulence of Clostridium difficile
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروب شناسی
پیش نمایش صفحه اول مقاله
The role of toxin A and toxin B in the virulence of Clostridium difficile
چکیده انگلیسی

During the past decade, there has been a striking increase in Clostridium difficile nosocomial infections worldwide predominantly due to the emergence of epidemic or hypervirulent isolates, leading to an increased research focus on this bacterium. Particular interest has surrounded the two large clostridial toxins encoded by most virulent isolates, known as toxin A and toxin B. Toxin A was thought to be the major virulence factor for many years; however, it is becoming increasingly evident that toxin B plays a much more important role than anticipated. It is clear that further experiments are required to accurately determine the relative roles of each toxin in disease, especially in more clinically relevant current epidemic isolates.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 20, Issue 1, January 2012, Pages 21–29
نویسندگان
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