کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3422529 1226769 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Eliminating latent tuberculosis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروب شناسی
پیش نمایش صفحه اول مقاله
Eliminating latent tuberculosis
چکیده انگلیسی

Tuberculosis is recognized as the world's leading bacterial cause of death. Yet 95% of infection is believed to exist in an asymptomatic ‘latent’ form that is defined not by the identification of bacteria, but by the host immune response in the form of reactivity to tuberculosis proteins in the tuberculin skin test. It seems likely that clinically defined latent tuberculosis actually represents a spectrum that runs from elimination of live bacilli to subclinical disease: hence, it might be unhelpful to use a single term to describe all these conditions. To support this view, here we focus on recent increased understanding of the heterogeneity in both bacillary physiology and host immune response that potentially illuminates new therapeutic and diagnostic approaches to this condition.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 17, Issue 5, May 2009, Pages 183–188
نویسندگان
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