کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3423117 1226990 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
To kill or not to kill, that is the question: cytocidal antimalarial drug resistance
ترجمه فارسی عنوان
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موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی انگل شناسی
چکیده انگلیسی


• Cytostatic versus cytocidal drug resistance.
• IC50 versus LD50 drug susceptibility assays.
• Genetics of static versus cidal chloroquine resistance.

Elucidating mechanisms of antimalarial drug resistance accelerates development of improved diagnostics and the design of new, effective malaria therapy. Recently, several studies have emphasized that chloroquine (CQ) resistance (CQR) can be quantified in two very distinct ways, depending on whether sensitivity to the growth inhibitory effects or parasite-kill effects of the drug are being measured. It is now clear that these cytostatic and cytocidal CQR phenotypes are not equivalent, and recent genetic, cell biological, and biophysical evidence suggests how the molecular mechanisms may overlap. These conclusions have important implications for elucidating other drug resistance phenomena and emphasize new concepts that are essential for the development of new drug therapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 30, Issue 3, March 2014, Pages 130–135
نویسندگان
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