کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3423302 1227015 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Purine salvage in Leishmania: complex or simple by design?
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی انگل شناسی
پیش نمایش صفحه اول مقاله
Purine salvage in Leishmania: complex or simple by design?
چکیده انگلیسی

Purine nucleotides function in a variety of vital cellular and metabolic processes including energy production, cell signaling, synthesis of vitamin-derived cofactors and nucleic acids, and as determinants of cell fate. Unlike their mammalian and insect hosts, Leishmania cannot synthesize the purine ring de novo and are absolutely dependent upon them to meet their purine requirements. The obligatory nature of purine salvage in these parasites, therefore, offers an attractive paradigm for drug targeting and, consequently, the delineation of the pathway has been under scientific investigation for over 30 years. Here, we review recent developments that reveal how purines flux in Leishmania and offer a potential ‘Achilles’ heel’ for future validation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 28, Issue 8, August 2012, Pages 345–352
نویسندگان
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