کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
342331 548811 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Brivaracetam inhibits spreading depression in rat neocortical slices in vitro
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Brivaracetam inhibits spreading depression in rat neocortical slices in vitro
چکیده انگلیسی

Epilepsy and migraine are episodic neurological disorders with marked co-morbidity, making migraine common among epileptic patients. Conversely, several antiepileptic drugs (AEDs) are used as migraine-preventive medication. Cortical spreading depression (CSD) represents a transient suppression of bioelectric activity and is considered a key event in migraine and stroke. This study assessed the novel AED candidate brivaracetam (BRV) vs. the chemically related AED levetiracetam in a rat neocortical slice model allowing consistent quantification of drug effects on CSD. CSD episodes were regularly elicited on slices upon delivery of calibrated KCl drops and were recorded via two micropipette electrodes. After control CSDs, the drug was added to the perfusion and five subsequent CSDs were elicited during drug perfusion. Effects were assessed via CSD amplitude (Ampl) and duration at half-amplitude (D1/2). BRV, 10 and 32 μM reduced the Ampl and transiently the D1/2. Levetiracetam, 32 and 100 μM had no effect on either Ampl or D1/2. The anti-CSD effect of BRV in this in vitro model might suggest a potential anti-migraine activity of this compound, which warrants further investigation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seizure - Volume 18, Issue 6, July 2009, Pages 453–456
نویسندگان
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