کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3423390 | 1227025 | 2012 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Host cell invasion by apicomplexans: what do we know?
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
انگل شناسی
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چکیده انگلیسی
Apicomplexan zoites enter host cells by forming and actively moving through a tight junction (TJ) formed between the parasite and host cell surfaces. Although the TJ was first described decades ago, its molecular characterization has proved difficult mainly because of its transient existence during an internalization process that lasts only seconds. In the past 7 years, work has led to a model of the TJ in which the association between AMA1 and RON proteins structures the TJ and bridges the cytoskeletons of the two cells. However, more recent work questions this view. Here, we critically discuss the current model and speculate on alternative models of the AMA1–RON association and of the apicomplexan TJ.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 28, Issue 4, April 2012, Pages 131–135
Journal: - Volume 28, Issue 4, April 2012, Pages 131–135
نویسندگان
Daniel Bargieri, Vanessa Lagal, Isabelle Tardieux, Robert Ménard,