کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
342350 548812 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Long-term efficacy and safety of lacosamide monotherapy in the treatment of partial-onset seizures: A multicenter evaluation
ترجمه فارسی عنوان
اثربخشی و ایمنی درازمدت تک سویه لکوسامید در درمان تشنجهای ناخواسته: یک بررسی چند مرکز
کلمات کلیدی
داروهای ضد صرع، صرع، تصرف، لاکوس امید، مونوتراپی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی


• We report clinical outcomes of lacosamide monotherapy in patients with focal epilepsy.
• Long-term seizure freedom was achieved in more than two-thirds of the patients.
• Tolerability was good and only few patients discontinued the drug due to side effects.

PurposeThe goal of this study is to report the efficacy and tolerability of lacosamide (LCM) monotherapy, as first-line and conversion regimens, in the treatment of patients with partial-onset seizures.MethodsWe retrospectively reviewed the charts of patients with focal epilepsy on LCM monotherapy from six centers in Spain. Efficacy and tolerability were evaluated in the overall group and in subgroups of patients who were naive to antiepileptic drug (AED) therapy (Group 1) and those who had previously been treated with AEDs (Group 2).ResultsSixty-six patients were identified including 18 patients in Group 1 and 48 patients in Group 2. Patients were followed up for 0.5–54 months in monotherapy (mean 15.5 months). Forty-two (63.6%) patients remained seizure-free during all the follow-up. At 6 and 12 months, seizure-free rates were 77.6% and 72.3%, respectively. The drug was withdrawn in 10 (15%) patients (3 side effects, 6 lack of efficacy, 1 other reason). Fifteen (22.7%) patients reported mild to moderate side effects with the use of LCM. No differences were found between Groups 1 and 2 regarding efficacy outcomes or tolerability issues.ConclusionsIn our series more than two-thirds of the patients remained seizure-free on LCM monotherapy. Side effects were generally mild and led to discontinuation in only 3/66 (4.5%) patients. Our experience suggests that LCM monotherapy, either as first-line or after conversion, may be a valuable option for patients with focal epilepsy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seizure - Volume 29, July 2015, Pages 119–122
نویسندگان
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