کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3423502 1227036 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Telomere biology of trypanosomatids: beginning to answer some questions
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی انگل شناسی
پیش نمایش صفحه اول مقاله
Telomere biology of trypanosomatids: beginning to answer some questions
چکیده انگلیسی

Studies of telomere structure and maintenance in trypanosomatids have provided insights into the evolutionary origin and conservation of some telomeric components shared by trypanosomes and vertebrates. For example, trypanosomatid telomeres are maintained by telomerase and consist of the canonical TTAGGG repeats, which in Trypanosoma brucei can form telomeric loops (t-loops). However, the telomeric chromatin of trypanosomatids is composed of organism-specific proteins and other proteins that share little sequence similarity with their vertebrate counterparts. Because telomere maintenance mechanisms are essential for genome stability, we propose that the particular features shown by the trypanosome telomeric chromatin hold the key for the design of antiparasitic drugs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 23, Issue 8, August 2007, Pages 357–362
نویسندگان
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