کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3423586 | 1227044 | 2010 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cathepsin B proteases of flukes: the key to facilitating parasite control?
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
انگل شناسی
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چکیده انگلیسی
Cysteine proteases are important virulence factors for parasites. This review will focus on the cathepsin B proteases of trematodes (also known as flukes) which are abundant in juvenile and immature flukes. Recent research, primarily in Fasciola, using inhibitors, RNA interference (RNAi) and vaccination studies indicates that cathepsin Bs play a key role in the biology of trematodes. As these proteases are largely expressed by infective parasite stages, their inactivation by chemotherapy or vaccination will greatly reduce the damage wrought by flukes as they invade host tissues. This validates cathepsin Bs as key strategic targets for fluke control.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 26, Issue 10, October 2010, Pages 506–514
Journal: - Volume 26, Issue 10, October 2010, Pages 506–514
نویسندگان
Peter M. Smooker, Rama Jayaraj, Robert N. Pike, Terry W. Spithill,