کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3423981 1227102 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The malaria parasite type II NADH:quinone oxidoreductase: an alternative enzyme for an alternative lifestyle
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی انگل شناسی
پیش نمایش صفحه اول مقاله
The malaria parasite type II NADH:quinone oxidoreductase: an alternative enzyme for an alternative lifestyle
چکیده انگلیسی

The operation of a type II NADH:quinone oxidoreductase (PfNDH2), also known as alternative Complex I, in the mitochondrion of the human malaria parasite, Plasmodium falciparum, has recently been described. Unlike the Complex I of typical mitochondria, type II NADH:quinone oxidoreductases do not have transmembrane domains and are not involved directly in proton (H+) pumping. Here, we present a predictive model of PfNDH2, describing putative NADH-, flavin- and quinone-binding sites, as well as a possible membrane ‘anchoring’ region. In addition, we hypothesize that the alternative Complex I is an evolutionary adaptation to a microaerophilic lifestyle enabling (proton) uncoupled oxidation of NADH. This adaptive feature has several advantages, including: (i) a reduction of proton ‘back-pressure’ in the absence of extensive ATP synthesis; (ii) a reduction of mitochondrial superoxide generation; and (iii) a mechanism for the deregulated oxidation of cytosolic NADH.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 23, Issue 7, July 2007, Pages 305–310
نویسندگان
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