کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3424217 1227203 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
miR-132 enhances HIV-1 replication
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
miR-132 enhances HIV-1 replication
چکیده انگلیسی

MicroRNAs upregulated during CD4+ T cell activation may contribute to the increased efficiency of HIV-1 replication seen following perturbation of the resting state. We have found miR-132 to be highly upregulated following CD4+ T cell activation, and show that miR-132 potentiates viral replication in the Jurkat CD4+ T cell line. Knockdown of MeCP2, a previously identified target of miR-132, also increases HIV-1 replication. To the best of our knowledge, miR-132 is the first miRNA reported to enhance HIV-1 replication.


► We found that miR-132 is highly upregulated upon CD4+ T cell activation.
► miR-132 potentiates HIV-1 replication in Jurkat cells.
► This is the first identification of a miRNA that enhances HIV-1 replication.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 438, Issue 1, 30 March 2013, Pages 1–4
نویسندگان
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