HTLV-1: Persistence and pathogenesis

► General method to identify the determinants of protective immunity and its application to HTLV-1.
► Observation made that “innate” KIR receptors enhance the HLA class I-restricted response in HTLV-1 infection.
► Description of the mechanisms of HTLV-1 persistence and of the importance of the viral protein HBZ.
► Observation made that CD8+ T cells kill infected, Tax-expressing cells in vivo at a slow rate.
► Description of the role of the HTLV-1 proviral integration site.