کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3424294 1227211 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Human herpesvirus 6 glycoprotein M is essential for virus growth and requires glycoprotein N for its maturation
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Human herpesvirus 6 glycoprotein M is essential for virus growth and requires glycoprotein N for its maturation
چکیده انگلیسی

Human herpesvirus 6 (HHV-6) is a T-lymphotropic virus belonging to the betaherpesvirus family. Several HHV-6-encoded glycoproteins are required for cell entry and virion maturation. Glycoprotein M (gM) is conserved among all herpesviruses, and therefore thought to have important functions; however, the HHV-6 g has not been characterized. Here, we examined the expression of HHV-6 g, and examined its function in viral replication, using a mutant and revertant gM. HHV-6 g was expressed on virions as a glycoprotein modified with complex N-linked oligosaccharides. As in other herpesviruses, HHV-6 g formed a complex with glycoprotein N (gN), and was transported from the endoplasmic reticulum to the trans-Golgi network only when part of this complex. Finally, a gM mutant virus in which the gM start codon was destroyed was not reconstituted, although its revertant was, indicating that HHV-6 g is essential for virus production, unlike the gM of alphaherpesviruses.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 429, Issue 1, 20 July 2012, Pages 21–28
نویسندگان
, , , ,