کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3424532 1227229 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Early immunopathology events in simian retrovirus, type 2 infections prior to the onset of disease
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Early immunopathology events in simian retrovirus, type 2 infections prior to the onset of disease
چکیده انگلیسی

Immunopathology during early simian retrovirus type 2 (SRV-2) infection is poorly characterized. Here, viral dynamics, immune response and disease progression in transiently- or persistently-infected cynomolgus macaques are assessed. Viral nucleic acids were detected in selected lymphoid tissues of both persistently- and transiently-infected macaques, even after viral clearance from the periphery. Immunohistochemical staining of lymphoid tissues revealed alterations in a number of immune cell populations in both transiently- and persistently-infected macaques. The precise pattern depended upon the infection status of the macaque and the marker studied. Gross immunopathological changes in lymphoid tissues were similar between SRV infection and those observed for other simian retroviruses SIV and STLV, suggesting a common immunopathological response to infection with these agents.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 413, Issue 2, 10 May 2011, Pages 161–168
نویسندگان
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