کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
342471 548827 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Uppermost synchronized generators of spike–wave activity are localized in limbic cortical areas in late-onset absence status epilepticus
ترجمه فارسی عنوان
اکثر ژنراتورهای همگام موجی از فعالیت اسپیکایا در ناحیه لگنی در قسمتهای قشر لنفاوی در اواخر تأخیر در وضعیت اپیلپتیکوس قرار دارند
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی

PurposeAbsence status (AS) epilepticus with generalized spike–wave pattern is frequently found in severely ill patients in whom several disease states co-exist. The cortical generators of the ictal EEG pattern and EEG functional connectivity (EEGfC) of this condition are unknown. The present study investigated the localization of the uppermost synchronized generators of spike–wave activity in AS.MethodSeven patients with late-onset AS were investigated by EEG spectral analysis, LORETA (Low Resolution Electromagnetic Tomography) source imaging, and LSC (LORETA Source Correlation) analysis, which estimates cortico-cortical EEGfC among 23 ROIs (regions of interest) in each hemisphere.ResultsAll the patients showed generalized ictal EEG activity. Maximum Z-scored spectral power was found in the 1–6 Hz and 12–14 Hz frequency bands. LORETA showed that the uppermost synchronized generators of 1–6 Hz band activity were localized in frontal and temporal cortical areas that are parts of the limbic system. For the 12–14 Hz band, abnormally synchronized generators were found in the antero-medial frontal cortex. Unlike the rather stereotyped spectral and LORETA findings, the individual EEGfC patterns were very dissimilar.ConclusionThe findings are discussed in the context of nonconvulsive seizure types and the role of the underlying cortical areas in late-onset AS. The diversity of the EEGfC patterns remains an enigma. Localizing the cortical generators of the EEG patterns contributes to understanding the neurophysiology of the condition.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seizure - Volume 23, Issue 3, March 2014, Pages 213–221
نویسندگان
, , , , , , ,