کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3424806 | 1227247 | 2011 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The role of Th17 cells and regulatory T cells in Coxsackievirus B3-induced myocarditis The role of Th17 cells and regulatory T cells in Coxsackievirus B3-induced myocarditis](/preview/png/3424806.png)
IL-17-producing (Th17) and regulatory T (Treg) cells have been well established in the pathogenesis of many inflammatory diseases. To assess whether Th17 and Treg were altered in acute virus-induced myocarditis (AVMC) mice, we assessed Th17/Treg functions on different levels in AVMC. It was shown that the expression of splenic Th17 cells and Th17-related cytokines (IL-17A, IL-21) markedly increased. Interestingly, the expression of splenic Treg cells and Treg-related cytokines (TGF-β, IL-10) also significantly increased. Using neutralization of IL-17 in the AVMC, we found that Treg cells roughly decreased compared with isotype control mice. However, T cells and perforin dramatically increased, followed by a marked reduction in CVB3 replication. The results suggested that Th17 cells possibly contributed to viral replication through the action of Treg cells in mediating T cells and perforin response in AVMC.
Journal: Virology - Volume 421, Issue 1, 5 December 2011, Pages 78–84