کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3425534 | 1227289 | 2010 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Role of BC loop residues in structure, function and antigenicity of the West Nile virus envelope protein receptor-binding domain III
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Role of BC loop residues in structure, function and antigenicity of the West Nile virus envelope protein receptor-binding domain III Role of BC loop residues in structure, function and antigenicity of the West Nile virus envelope protein receptor-binding domain III](/preview/png/3425534.png)
چکیده انگلیسی
Site-directed mutagenesis of residues in the BC loop (residues 329–333) of the envelope (E) protein domain III in a West Nile virus (WNV) infectious clone and in plasmids encoding recombinant WNV and dengue type 2 virus domain III proteins demonstrated a critical role for residues in this loop in the function and antigenicity of the E protein. This included a strict requirement for the tyrosine at residue 329 of WNV for virus viability and E domain III folding. The absence of an equivalent residue in this region of yellow fever group viruses and most tick-borne flavivirus suggests there is an evolutionary divergence in the molecular mechanisms of domain III folding employed by different flaviviruses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 403, Issue 1, 20 July 2010, Pages 85–91
Journal: Virology - Volume 403, Issue 1, 20 July 2010, Pages 85–91
نویسندگان
Shuliu Zhang, Evgeniy I. Bovshik, Rodrigo Maillard, Gregory D. Gromowski, David E. Volk, Catherine H. Schein, Claire Y.-H. Huang, David G. Gorenstein, James C. Lee, Alan D.T. Barrett, David W.C. Beasley,