کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3425639 1227293 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Differential patterns of immune escape at Tat-specific cytotoxic T cell epitopes in pigtail macaques
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Differential patterns of immune escape at Tat-specific cytotoxic T cell epitopes in pigtail macaques
چکیده انگلیسی

Cytotoxic T lymphocyte responses to conserved proteins such as Gag within HIV- or SIV-infected hosts can facilitate partial control of viremia. However, the utility of targeting variable viral proteins by CTL responses is unclear. We studied CTL responses to regulatory and accessory proteins of SIV in pigtail macaques. The regulatory and accessory proteins were the most commonly targeted proteins by CTL responses from pigtail macaques. We identified 2 novel Tat-specific CTL responses that were both restricted by the Mane-A⁎10 allele. Viral escape at one of the Tat epitopes, KSA10, was slower in comparison to another Tat epitope KVA10. The kinetics of escape of the KSA10 Tat epitope were more similar to an immunodominant KP9 Gag epitope also restricted by Mane-A⁎10. Our results suggest that some regulatory or accessory CTL epitopes may be useful targets for vaccination against HIV.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 388, Issue 2, 5 June 2009, Pages 315–323
نویسندگان
, , ,