کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3425649 1594269 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The ribosomal protein L10/QM-like protein is a component of the NIK-mediated antiviral signaling
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
The ribosomal protein L10/QM-like protein is a component of the NIK-mediated antiviral signaling
چکیده انگلیسی

The NIK (NSP-interacting kinase)-mediated antiviral signaling pathway was identified as a virulence target of the begomovirus nuclear shuttle protein (NSP). Here, we further characterized this layer of plant innate defense by identifying the ribosomal protein L10 (rpL10), a QM-like protein, as a downstream effector of the antiviral signaling. Although both ribosomal proteins rpL10 and rpL18 were found to associate with NIK1 through yeast two-hybrid screening, the NIK receptors specifically phosphorylated rpL10 in vitro. Furthermore, loss of rpL10 function significantly increased susceptibility to begomovirus infection, recapitulating the phenotype of nik knockout lines. Our results genetically linked rpL10 to the NIK-mediated antiviral signaling.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 380, Issue 2, 25 October 2008, Pages 165–169
نویسندگان
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