کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3425849 1227302 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
MYMIV replication initiator protein (Rep): Roles at the initiation and elongation steps of MYMIV DNA replication
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
MYMIV replication initiator protein (Rep): Roles at the initiation and elongation steps of MYMIV DNA replication
چکیده انگلیسی

In order to explore the mechanism of geminivirus DNA replication, we show that the Replication initiator (Rep) protein encoded by Mungbean yellow mosaic India virus (MYMIV), a member of the family Geminiviridae, binds specifically to the iterons present in the viral DNA replication origin (CR-A) in a highly ordered manner that might be a prerequisite for the initiation of replication. MYMIV Rep also acts as a helicase during the post-initiation stage and is upregulated in presence of the RPA32 subunit of Replication Protein A. The implication of these findings on the initiation and elongation stages of MYMIV DNA replication has been discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 380, Issue 1, 10 October 2008, Pages 75–83
نویسندگان
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