کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3425893 | 1227304 | 2007 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Knock-in of the Oas1br allele into a flavivirus-induced disease susceptible mouse generates the resistant phenotype
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Inheritance patterns in mice suggested that resistance to flavivirus-induced disease was conferred by a single autosomal dominant allele (Flvr). A positional cloning strategy followed by comparison of Flv interval gene sequences from congenic resistant C3H.PRI-Flvr and susceptible C3H/He mouse strains identified the 2′–5′-oligoadenylate synthetase 1b (Oas1b) gene as Flv. However, since these mouse strains differ by a 31 cM region, the possible involvement of differences in other linked genes in the resistant phenotype could not be absolutely ruled out. Knock-in of the Oas1b resistance allele into a susceptible mouse strain produced mice with the flavivirus resistance phenotype, confirming that this phenotype is mediated by a single gene.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 368, Issue 2, 25 November 2007, Pages 232–237
Journal: Virology - Volume 368, Issue 2, 25 November 2007, Pages 232–237
نویسندگان
Svetlana V. Scherbik, Kerri Kluetzman, Andrey A. Perelygin, Margo A. Brinton,