کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3425893 1227304 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Knock-in of the Oas1br allele into a flavivirus-induced disease susceptible mouse generates the resistant phenotype
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Knock-in of the Oas1br allele into a flavivirus-induced disease susceptible mouse generates the resistant phenotype
چکیده انگلیسی

Inheritance patterns in mice suggested that resistance to flavivirus-induced disease was conferred by a single autosomal dominant allele (Flvr). A positional cloning strategy followed by comparison of Flv interval gene sequences from congenic resistant C3H.PRI-Flvr and susceptible C3H/He mouse strains identified the 2′–5′-oligoadenylate synthetase 1b (Oas1b) gene as Flv. However, since these mouse strains differ by a 31 cM region, the possible involvement of differences in other linked genes in the resistant phenotype could not be absolutely ruled out. Knock-in of the Oas1b resistance allele into a susceptible mouse strain produced mice with the flavivirus resistance phenotype, confirming that this phenotype is mediated by a single gene.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 368, Issue 2, 25 November 2007, Pages 232–237
نویسندگان
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