کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3426036 1227311 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Characteristics of hepatitis B virus genotype G coinfected with genotype H in chimeric mice carrying human hepatocytes
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Characteristics of hepatitis B virus genotype G coinfected with genotype H in chimeric mice carrying human hepatocytes
چکیده انگلیسی

Accumulated evidence indicated that hepatitis B virus genotype G (HBV/G) is present exclusively in coinfection with other HBV genotypes. In Mexico, HBV/G from 6 men who had sex with men were coinfected with HBV/H. Phylogenetically complete genomes of the 6 Mexican HBV/G strains were closely related to previous ones from the US/Europe. Using uPA/SCID mice with human hepatocytes, monoinfection with HBV/G did not result in detectable HBV DNA in serum, whereas superinfection with HBV/G at week 10 inoculated HBV/H when HBV/H DNA was elevated to > 107 copies/mL has enhanced the replication of HBV/G. The HBV/G was enhanced in another 3 inoculated with a serum passage containing HBV/G with a trace of HBV/H. Coinfection of mice with HBV/G and H induced fibrosis in the liver. In conclusion, the replication of HBV/G can be enhanced remarkably when it is coinfected with HBV/H. Coinfection with HBV/G may be directly cytopathic in immunosuppressive conditions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 376, Issue 2, 5 July 2008, Pages 408–415
نویسندگان
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