کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3426335 1227326 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Comparative transforming potential of different human papillomaviruses associated with non-melanoma skin cancer
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Comparative transforming potential of different human papillomaviruses associated with non-melanoma skin cancer
چکیده انگلیسی

It is well established that high-risk human papillomaviruses (HPVs) that infect mucosal epithelia are the causative agents of cervical cancer. In contrast, the association of cutaneo-tropic HPV types with the development of non-melanoma skin cancer (NMSC) is less well defined. In this study, we have analysed the in vitro transforming potential of various cutaneous HPV types. Using oncogene cooperation assays with activated ras, we have shown that diverse cutaneous types, including 12, 14, 15, 24, 36 and 49, have significant transforming potential. Interestingly, most of this activity appears to be encoded by the E6 gene product. In contrast, the common HPV-10 exhibits no significant transforming potential in these assays. This difference may be a reflection of different patterns of cellular localization, with transforming E6s being nuclear and non-transforming being cytoplasmic. These results provide molecular support for a role of these viruses in the development of certain human malignancies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 371, Issue 2, 20 February 2008, Pages 374–379
نویسندگان
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