کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3426781 | 1227344 | 2006 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Functional human endogenous retroviral LTR transcription start sites are located between the R and U5 regions Functional human endogenous retroviral LTR transcription start sites are located between the R and U5 regions](/preview/png/3426781.png)
Human endogenous retroviruses (HERVs) occupy about 5% of human DNA and are thought to be remnants of ancient retroviral infections of human ancestors' germ cells. HERVs can modify expression of host cell genes through their cis-regulatory elements concentrated in their long terminal repeats (LTRs). Although numerous HERV-related RNAs were identified in the human transcriptome, for most of them, it remains unclear whether they are LTR-promoted or read-through products initiated from neighboring genomic promoters. Here, we describe mapping of transcriptional start sites within solitary and proviral LTRs of the HERV-K (HML-2) human-specific subfamily of endogenous retroviruses. Surprisingly, the transcription was initiated predominantly from the very 3′ termini of the LTR R regions. The data presented here may shed light on adaptive coevolution of human endogenous retroviruses with their host cells.
Journal: Virology - Volume 346, Issue 2, 15 March 2006, Pages 373–378