کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3426790 1227344 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Maturation of the viral core enhances the fusion of HIV-1 particles with primary human T cells and monocyte-derived macrophages
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Maturation of the viral core enhances the fusion of HIV-1 particles with primary human T cells and monocyte-derived macrophages
چکیده انگلیسی

HIV-1 infection requires fusion of viral and cellular membranes in a reaction catalyzed by the viral envelope proteins gp120 and gp41. We recently reported that efficient HIV-1 particle fusion with target cells is linked to maturation of the viral core by an activity of the gp41 cytoplasmic domain. Here, we show that maturation enhances the fusion of a variety of recombinant viruses bearing primary and laboratory-adapted Env proteins with primary human CD4+ T cells. Overall, HIV-1 fusion was more dependent on maturation for viruses bearing X4-tropic envelope proteins than for R5-tropic viruses. Fusion of HIV-1 with monocyte-derived macrophages was also dependent on particle maturation. We conclude that the ability to couple fusion to particle maturation is a common feature of HIV-1 Env proteins and may play an important role during HIV-1 replication in vivo.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 346, Issue 2, 15 March 2006, Pages 460–468
نویسندگان
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