کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3426941 1227353 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
SIV Vpr evolution is inversely related to disease progression in a morphine-dependent rhesus macaque model of AIDS
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
SIV Vpr evolution is inversely related to disease progression in a morphine-dependent rhesus macaque model of AIDS
چکیده انگلیسی

Three of six morphine-dependent monkeys progressed rapidly to AIDS and died by 20 weeks in our SIV/SHIV non-human primate model of drug addiction and AIDS. We studied the evolution of the SIV vpr gene in both cerebrospinal fluid (CSF) and plasma in these rapid progressors, in their normal progressor counterparts and in infected, drug-free controls at 12 and 20 weeks post infection. Viral RNA was amplified, cloned, and sequenced to permit phylogenetic analyses of diversity and divergence of the vpr locus. As we found for SIV tat and env, the vpr gene evolves inversely to the rate of disease progression. Further, we found evidence that compartmentalization of the virus in plasma and CSF is significantly greater in the normal progressors than in the morphine-dependent, rapid progressors. Interestingly, although our previous work with the accessory gene nef indicated no association between disease progression and evolution, the accessory factor, vpr, behaves similarly to the essential lentiviral genes tat and env.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 359, Issue 2, 15 March 2007, Pages 397–404
نویسندگان
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