کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3426964 1227354 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Protein kinase CK2 phosphorylates the Nef protein from a neurovirulent simian immunodeficiency virus
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Protein kinase CK2 phosphorylates the Nef protein from a neurovirulent simian immunodeficiency virus
چکیده انگلیسی

The Nef protein of Human Immunodeficiency Virus (HIV) and Simian Immunodeficiency Virus (SIV) is a pluripotent accessory protein that plays a critical role in disease progression. One analogous characteristic of Nef proteins from SIV and HIV is the ability to associate with cellular kinases. We have previously reported that the Nef protein from a macrophage-tropic neurovirulent SIV clone, SIV/17E-Fr, is associated with an unknown kinase activity that is distinct from the p21-associated kinase that interacts with SIVmac239 Nef. Using site-directed mutagenesis and kinase-specific inhibitors, we have identified this kinase as the ubiquitous serine/threonine kinase, protein kinase CK2.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 348, Issue 1, 25 April 2006, Pages 156–164
نویسندگان
, , ,