کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3427035 1227357 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Redefining the common insertion site
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Redefining the common insertion site
چکیده انگلیسی

Retroviral mutagenesis has been used as a powerful tool to discover genes involved in oncogenesis through a technique called Common Insertion Site (CIS) analysis where tumors are induced by proviral integrations and the genomic loci of the proviruses are identified. A fundamental assumption made in this analysis is that multiple proviral insertions in close proximity occurring more frequently than would be predicted randomly provides evidence that the genes near the integrations are involved in the formation of the tumors. We demonstrate here using data derived from MLV integrations not put under selection for tumor induction that CIS analysis as currently defined is often not a sufficient argument for a gene's significance in tumorigenesis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 344, Issue 2, 20 January 2006, Pages 292–295
نویسندگان
, , ,