کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3427358 1227387 2007 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Virus-specific T cell responses in macaques acutely infected with SHIVsf162p3
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Virus-specific T cell responses in macaques acutely infected with SHIVsf162p3
چکیده انگلیسی

CD4+ T helper and CD8+ cytotoxic T lymphocyte responses are believed to play an important role in the control of primary HIV and SIV infection. However, the role of these cells in macaques acutely infected with SHIVsf162p3 has not been well characterized. In this study, ten adult rhesus macaques were intravaginally infected with SHIVsf162p3, and antigen-specific cytokine responses to SHIV-Tat, Nef, Gag and Env peptide pools were examined through 70 days post inoculation (p.i.) using ELISPOT and/or cytokine flow cytometry (CFC). Peak plasma viral replication occurred between 14 and 21 days p.i. followed by low to undetectable plasma viremia by 70 days of infection in most macaques. Although some animals had strong virus-specific cellular immune responses, many had weak or minimal responses that did not correlate with the post peak decline in plasma viremia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 363, Issue 1, 20 June 2007, Pages 36–47
نویسندگان
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